With that in mind, it’s probably safe to say that fish are friends (and not just food). and worldwide so, many lives can be saved with the help of a little striped fish, like Dory. Heart disease is the leading cause of death in the U.S. Therefore, scientists are using the zebrafish to figure out what factors or pathways are involved in that process, so they may be able to help the human heart heal itself after being damaged during a heart attack. The zebrafish heart, on the other hand, has the capability to regenerate and replace injured heart tissue after damage. One of the major reasons why people succumb to heart attacks is because heart cells get damaged and die heart cells have little to no capability to regenerate (make more of themselves). Zebrafish organs or tissues can be easily visualized because they are see-through In addition, zebrafish heart models have provided genetic evidence that certain signaling pathways protect humans against heart problems. Zebrafish models of heart failure have been found to exhibit similar defects to those found in patients with heart disease. Therefore, the zebrafish model allows scientists to follow a disease longer than they would be able to in a mouse model. For example, zebrafish are an advantageous model for studying congenital heart disease because they can survive severe cardiac defects that are typically lethal in mice. Other advantages of the zebrafish are disease specific. Imagine being able to see individual cells migrate from one location to the next and form an entire heart that begins to beat 24 hours later- in real time. The zebrafish is see-through fluorescence markers can be used to “highlight” various cells in tissues and organs.This allows for more cost effective and faster identification of new drugs and new uses for current drugs. In zebrafish, important pathways can be easily blocked and examined by simply adding the drug to the water.Picture above shows zebrafish blood vessels labelled in red and lymphatic vessels labelled in green Zebrafish can easily be genetically manipulated to study a disease it takes less time to generate a zebrafish mutant line than a mouse mutant line.Zebrafish reproduce more frequently (every week) than mice and rats.Zebrafish models actually have many advantages over mouse or rat models: You might also be wondering why not use mice? After all, they’re at least mammals. Good question! In fact, according to a paper published in Nature, 84% of genes known to be associated with human disease have a zebrafish counterpart. However, zebrafish are much more similar to people than one might initially think. You might be thinking that there is no way a 3-5 cm fish, with fins and no lungs, can model human disease humans are extremely different from zebrafish. The zebrafish is a tropical freshwater fish that is currently used in many research labs as a powerful model organism for studying various diseases such as heart disease, cancer, diabetes, and gastrointestinal disease. Just like Nemo, humans have their own fish hero too: the zebrafish.
Who would have thought that the loopy blue tang fish would be the unsung hero? Zebrafish ( Danio rerio), possibly the key to treat/cure heart disease However, what about Dory? Though some might characterize Dory as loopy, she was the real hero who saved Marlin and Nemo’s lives and reunited father and son. Or, they might remember Marlin, the overprotective father. When most people think about “Finding Nemo,” they likely think about Nemo, the adventurous young clownfish who got caught up in a fishy situation (no pun intended) and ended up in a dentist’s fish tank. On my honor, so help me.Repeat after me: “Fish are friends, not food” I promise to watch all the making-of features, listen to the complete audio-visual commentary, and search diligently for Easter Eggs. Choose the commentary!Īll scientific exploration is an act of discovery, so pick a button and discover what happens. Well, they might listen to me I speak mammal. Unique Fish Are Friends Not Food stickers featuring millions of original designs created and sold by independent artists. Uh! I'd like to see it with the commentary! Okay, optical orbits up front, and let's pick a button. Welcome explorers! So much to see, so much to learn. Let's make a selection on the D-V-D! Ohhhhh! Pick something. Let's make a selection, a selection, a selection.
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